A Comprehensive Review of the Biological Activities of MedicinalMetal Complexes Synthesized From Quinoline Scaffolds

Abstract

Te compelling attributes of quinoline scafolds in medicinal compounds have garnered considerable attention from researchers,due to their notable biological efcacy, biocompatibility, and distinctive photophysical properties. Quinoline complexes, inparticular, have emerged as signifcant entities, demonstrating a wide array of medicinal properties, including antibacterial,antifungal, antiviral, anticancer, anthelmintic, anti-HIV, antioxidant, antituberculosis, and antimalarial activities. In addition,they showed promise in photodynamic and neurological studies, along with strong DNA-binding capabilities. In recent years(2010–2023), substantial progress has been made in understanding quinoline complexes. Key aspects such as the lipophilicity, ofmetal complexes, enzymatic drug degradation factors infuencing inhibition, drug performance, disruption of target cell growth,and their impact on DNA have been thoroughly investigated. Researchers have employed advanced methodologies includingfuorescent imaging, determination of MIC and IC50 values, hydrodynamic and spectrophotometric techniques, in silico andin vitro studies, and cytotoxicity assessments using the MTT method, to signifcantly enhance our understanding of thesecomplexes. Recent fndings indicated that the interaction of quinoline complexes with viral proteins and their ability to disruptenzyme-viral DNA relationships have made them powerful therapeutic agents for severe diseases including cancer, AIDS, andcoronaviruses, as well as various neurological and microbial infections. It is anticipated that these explorations will lead to efectiveadvancements in therapeutic strategies within modern medicine