| Authors | Hamid Beyzae,Reza Aryan, |
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| Journal | Avicenna Journal of Medical Biochemistry |
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| Page number | 9-15 |
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| Serial number | 7 |
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| Volume number | 1 |
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| Paper Type | Full Paper |
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| Published At | 2019 |
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| Journal Type | Typographic |
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| Journal Country | Iran, Islamic Republic Of |
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| Journal Index | isc |
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| Keywords | Antibacterial Evaluation, Quinolinecarboxaldehyde, antimicrobial agents, Schiff base |
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Abstract
Background: Design, identification, and synthesis of new antimicrobial agents along with preventive
proceedings are essential to confront antibiotic-resistant pathogenic bacteria. Heterocyclic Schiff bases
are biologically important compounds whose antimicrobial potentials have been proven to bacterial and
fungal pathogens.
Objectives: In this study, some quinoline Schiff bases were synthesized from condensation of 2-chloro-
3-quinolinecarboxaldehyde and aniline derivatives. Their inhibitory activities were evaluated against 6
gram-positive and 2 gram-negative bacterial pathogens.
Methods: Disc diffusion, broth microdilution, and time-kill tests were applied according to the CLSI
guidelines to determine IZD, MIC, and MBC values.
Results: 2-Chloro-3-quinolinecarboxaldehyde Schiff bases could inhibit the growth of bacteria with IZDs
of 7.5-19.8 mm, MICs of 256-2048 μg mL-1, and MBCs of 512 to ≥2048 μg mL-1.
Conclusion: Moderate antibacterial effects were observed with heterocyclic Schiff bases. Complexation
and structural changes can improve their antimicrobial properties.
Keywords: Antibacterial effect, Broth microdilution, Disc diffusion, In vitro study, Quinoline Schiff base,
Time-kill
