Electrochemical sensor for simple and sensitive ultra-trace detection of sunitinib in different samples

چکیده مقاله

The electrochemical methods using glassy carbon electrode (GCE) have been widely used as sensitive and selective analytical methods for the environmental, clinical and bio technical analysis [1]. Using of electrochemical sensors and biosensors is increase so much for biological and environmental samples. Because they have so many advantages like very low background current, low cost and simple method, large potential window, simple surface renewal process, easiness of miniaturization, good linearity range and good limit of detection [2,3]. Sunitinib (SUN) has proven efficacy as a single agent in several solid tumor types and is approved for use in advanced renal cell cancer and imatinib resistant or imatinibintolerant gastrointestinal stromal tumors [4]. SUN was recently approved for the treatment of advanced renal cell carcinoma and for the treatment of gastrointestinal stromal tumors after disease progression or intolerance to imatinib mesylate therapy [5]. We are introducing a new sensor for trace determination of SUN in different samples. The electrochemical response characteristic of the GCEtoward SUN was investigated by cyclic and square wave voltammetry (CV and SW). Electrochemical studies were carried out in a glass cell incorporating three electrode configuration containing 25 mL, 0.1 M phosphate buffer solution (pH 7.0) as running electrolyte, powered by a CompactStativium. The working electrode used in the voltammetry experiments was a GCE (without any accumulation time) and a platinum wire was used as the counter electrode and reference electrode was saturated calomel electrode. The figures of merit of proposed sensor and the other methods was reported in table. As shown in the table, the response of proposed sensor under the optimized conditions was acceptable. The RSD of five replicate experiment was