| نویسندگان | soheyla alipour nooghabi,,Hamid Beyzaei |
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| نشریه | Heliyon |
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| شماره صفحات | 2-11 |
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| شماره سریال | 2023 |
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| شماره مجلد | 9 |
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| نوع مقاله | Full Paper |
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| تاریخ انتشار | 2023 |
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| نوع نشریه | چاپی |
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| کشور محل چاپ | ایران |
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| نمایه نشریه | ISI،JCR،Scopus |
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چکیده مقاله
In recent years, the scientific community has focused on traditional natural products and their
potential therapeutic benefits. Berberine is a plant-derived isoquinoline alkaloid with a variety of
biological properties and identified as a promising pharmacophore for discovering new therapeutic
agents against various diseases. However, unfavorable pharmacokinetic properties of
berberine have limited its clinical application so much that researchers pursue its structure
modification to overcome this problem. This study focuses on the synthesis of new berberine
derivatives to improve its antioxidant and antimicrobial potentials, which were characterized
using CHNO and NMR instruments. Berberine extracted from barberry root was nitrated, reduced
to amine and condensed with benzaldehyde derivatives to produce berberine-based Schiff bases.
The H atom donating ability of all compounds was measured against DPPH free radicals, with IC50
values ranging from 18.28 to 108.20 μg ml
لینک ثابت مقاله
