| Authors | Hossein Javdani,Farzaneh Karimi,Shiva Mahmoudi,Ali Farahi,Mohamad Javad Mirzaei-Parsa,Arman Shahabi |
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| Journal | Molecular Biology Reports |
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| Page number | 9963-9973 |
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| Serial number | 49 |
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| Paper Type | Full Paper |
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| Published At | 2022 |
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| Journal Type | Typographic |
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| Journal Country | Netherlands |
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| Journal Index | ISI،JCR،Scopus |
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Abstract
Despite major advances, breast cancer (BC) is the most commonly diagnosed carcinoma and remains a deadly disease
among women worldwide. Many researchers point toward an important role of an epithelial to mesenchymal transition
(EMT) in BC development and promoting metastasis. Here, will be discussed that how functional changes of transcription
factors, signaling pathways, and microRNAs (miRNA) in BC promote EMT. A thorough understanding the EMT biology
can be important to determine reversing the process and design treatment approaches. There are frequent debates as to
whether EMT is really relevant to BC in vivo, in which due to the intrinsic heterogeneity and tumor microenvironment.
Nevertheless, given the importance of EMT in cancer progression and metastasis, the implementation of therapies against
cancer-associated EMT will continue to help us develop and test potential treatments.
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