| نویسندگان | Keyhandokht Karimi Shahri,Najmeh Mohammadi |
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| نشریه | Biomedical Physics and Engineering Express |
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| شماره صفحات | 1-14 |
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| شماره سریال | 11 |
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| شماره مجلد | 4 |
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| نوع مقاله | Full Paper |
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| تاریخ انتشار | 2025 |
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| نوع نشریه | چاپی |
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| کشور محل چاپ | ایران |
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| نمایه نشریه | Scopus |
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چکیده مقاله
Thisstudyaimedtoinvestigatetheeffectoftissuecalcificationonthedosedistributionoflow-energy
brachytherapyseedsusedinthetreatmentofprostateandbreasttumors.Toachievethis,simulations
of theIR-125Iand131Cs-1seedswereconductedusingtheMCNPXMonteCarlo(MC)code.
Brachytherapydosimetricparameters,suchasthedoserateconstant (L)andradialdosefunction(g
(r)), werecalculated inwaterfollowingtheTG-43U1protocolandvalidatedbycomparingtheresults
withdatareportedinotherliterature.Thefindingsrevealedsignificantuncertaintyintheg(r)for
calcifiedtissue oftheprostate, adipose,andglandularbreastcomparedtonormaltissue.Theg(r)value
showedanotableincreaseinthevicinityoftheseeds(within1cmfromthecenteroftheseeds),
followedbyadecrease.Thistrendwasobservedinallthreetissues.Thehigherthepercentageof
calcification inthetissue, themorepronouncedthechanges.Theg(r)increasedbyafactorof266and
102forIR-125I,and131Cs-1seeds,respectively, inthe100%calcifiedprostate.Thetrendofg(r)
changesalignedwiththetrendofchangesinthemassattenuationcoefficientscalculatedforthetissues
at different calcification percentages. Anexponentialfunction(Aexp(-r/t))wasderivedtopredictg(r)
acrossvariouscalcificationpercentages.Additionally, theinsightsgainedfromthisstudymayapplyto
othersofttissues
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