A new intervention strategy for an HIV/AIDS transmission by a general fractional modeling and an optimal control approach

Abstract

This study proposes a new mathematical model in a generalized fractional framework for the investigation of an HIV/AIDS transmission dynamics. An auxiliary parameter further prevents the fractional equations from mismatching in the dimension. In order to analyze the general model, the non-negativity of the solution and the stability of the equilibrium points are examined. The model is also implemented by a powerful numerical scheme based on the quadrature rules and the repeated Trapezoidal method; as well, the error discussion and the convergence analysis are established. In addition, an efficient intervention strategy is developed and examined based on the optimal control theories in terms of optimality necessary conditions. Real-life clinical observations from Cape Verde Islands show that the new fractional model outperforms the classical one with ordinary time-derivatives, and enhances the modeling output compared to the previous fractional mathematical results. Further, numerical simulations demonstrate that the proposed optimal control measure leads to a significant reduction in the disease spread. As a result, the general fractional model offers a degree-of-freedom, an efficient tool which is helpful to illustrate the fundamental features of the disease transmission and to increase the efficiency of the proposed treatment strategy.