| Authors | Seyed Mousa Mousavi-Kouhi,Morteza Ghorbany,Hossein Hammami |
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| Journal | بین المللی نانو علم و فناوری - International Journal of NanoScience and Nanotechnology |
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| Page number | 209-217 |
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| Serial number | 18 |
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| Volume number | 3 |
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| Paper Type | Full Paper |
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| Published At | 2022 |
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| Journal Grade | Scientific - research |
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| Journal Type | Typographic |
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| Journal Country | Iran, Islamic Republic Of |
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| Journal Index | isc،Scopus |
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Abstract
A meta-analysis on two microarray-based data was performed to identify the statistically enriched
gene sets in Arabidopsis thaliana treated with nanoparticle (NPs) using Gene Set Enrichment Analysis
(GSEA) based on Kyoto Encyclopedia of Genes and Genomes (KEGG). Log fold change (FC) of the gene
expression under NPs treatment, compared to the control, was manually calculated in excel after data
merging, to find gens with the highest expression under the treatment. GSEA analysis revealed that
under NPs treatment, different pathways related to organ morphogenesis, cell adhesion molecule
binding, epithelial development, immune response regulating signaling pathway, regulatory region
nucleic acid binding, supramolecular complex, taxis (directed movement in response to stimulus), tube
development, and vacuole were differentially expressed. Top 10 up-regulated genes under NPs treatment
based on the Enrichment Score (ES) were AT1G69510, AT5G29000, AT3G17880, AT5G14590,
AT5G57655, AT2G30530, AT1G55530, AT1G01770, AT2G17220, and AT2G25460. Many of these genes
are involved in the response to stress and in the plant defense signaling.
Paper URL
