Effect of high intensity interval training along with Oligopin supplementation on some inflammatory indices and liver enzymes in obese male Wistarratswithnon-alcoholicfattyliverdisease

Abstract

Background: Thepurposeofthisstudywastodeterminetheeffectofhigh-intensityintervaltrainingwithand withoutOligopinsupplementationonsomeinflammatoryindicesandliverenzymesinobesemaleWistarrats withnon-alcoholicfattyliverdisease.Methods:36adultmaleWistarratsweredividedintofivegroupsincluding normal diet sedentary (ND-SED), high-fat diet sedentary (HFD-SED), high-fat diet & high-intensity interval training(HFD-HIIT),high-fatdiet&Oligopin(HFD-O),high-fatdiet&high-intensityintervaltraining&Oligopin (HFD-HIIT+O).Firstly,inordertoinducefattyliver,high-fatfoodwasusedfor12weeks. Results: EightweeksofHIITledtoasignificantdecreaseofinterlucin-6(IL-6),tumornecrosisfactor-alpha(TNFα)andaspartateaminotransferase(AST)inplasmalevelsandasignificantincreaseofVO2max.Besides,eightweek administration of supplementary Oligopin resulted in a significant decrease of AST and alanine transaminase(ALT)whilenosignificantchangewasseeninthelevelsofTNF-αandIL-6.Inaddition,HIITwithan administrationofOligopinsupplementationledtoagreaterdecreaseinAST,ALT,IL-6,TNF-α. Conclusions: This study suggests that HIIT and Oligopin result in improving NAFLD disease caused by HFD. However,HIITandOligopinsupplementationarethemosteffectiveifcombined.