A Green Procedure for One-Pot Synthesis of Quinazolinone Derivatives Using CuFe2O4@SO3H as an Efficient and Reusable Catalyst under Solvent-Free Conditions

Abstract

Multicomponent reactions (MCRs) are special types of synthetically useful organic reactions in which three or more different starting materials react to give a final product in a one-pot procedure [1,2].2,3-Dihydroquinazolin-4(1H)-ones are important class of heterocycles with a wide range of pharmacological and biological activities [3]. A number of synthetic methods to prepare these compounds have been described in the past few years. Developments of magnetic nanoparticles (MNPs) for use as supports and investigations of their catalytic applications indicate an important branch of green nanotechnology as they enable environmentally friendly and sustainable catalytic processes. By easy recoverable MNPs from reaction media, various protocols by surface modification, binding and self-assembly offer a broad scope of approaches for preparing magnetically recyclable catalysts. Copper/iron oxide-based catalysts are environmentally compatible, air and moisture insensitive and separation of the reaction mixture is very easy by using an external magnetic field. Surface modified copper/iron oxide MNPs are a kind of new functional materials which have been widely used in biotechnology and analysis. In this research, we report a new, simple, mild, and effective procedure for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives via a multi-component condensation reaction between aryl aldehydes, isatoic anhydridesand ammonium acetate or amines in the presence of CuFe2O4@SO3H as catalyst with high yields (72-95%) and short time. In conclusion we have developed a facile, convenient and environment-friendly multicomponent protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones under green condition.