Authors | Mohammad ali Nasseri,,Ali Allahresani |
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Conference Title | بیست و ششمین سمینار شیمی آلی انجمن شیمی ایران |
Holding Date of Conference | 2019-03-12 |
Event Place | زابل |
Page number | 0-0 |
Presentation | POSTER |
Conference Level | Internal Conferences |
Abstract
Benzodiazepines and their polycyclic derivatives are an important class of bioactive compounds. Many functionalized benzodiazepines are widely used as anti-convulsant, antianxiety, analgesic, sedative, anti-depressive and hypnotic agents. These compounds also, finding applications as dyes for acrylic fibers and anti-inflammatory agents. 1,5- Benzodiazepines are key intermediates for the synthesis of various fused ring compounds such as triazolo-, oxadiazolo- and oxizino-diazepines [1]. Due to their broad spectrum of biological activity, these compounds received a lot of attention towards their synthesis. The general method for the synthesis of 1,5-benzodiazepines involves an acid-catalyzed condensation of o-phenylenediamines with α,β-unsaturated carbonyl compounds or β-halo ketones or ketones. Many reagents have been utilized for this reaction including polyphosphoric acid-SiO2, BF3·OEt2, NaBH4, Yb(OTf)3, MgO-POCl3, and more recently acetic acid under microwave conditions [2]. In continuation of our research towards the synthesis of biologically important molecules in this study various 1,5-benzodiazepine derivatives were synthesized by the condensation reaction of o-phenylenediamine with various ketones using the Fe3O4@SiO2-Cusalen [3] as an efficient, heterogeneous magnetically recyclable catalyst (Fig. 1).
tags: Benzodiazepines