Optimal Synthesis Conditions of Products from Carbon-Nitrogen Coupling Reaction Using Suitable Substrate Magnetic Nanocatalyst

Abstract

Carbon-nitrogen coupling reactions have been named in honor of Mr. Buchwald, which are very important in the medical industry for the production of biological products [1]. Every year, many articles are published and published on this subject, each of which has its own important and special features. In this project, the main purpose is to investigate the efficiency of nanocatalysts containing morpholine linkers and silica coatings with copper metal loaded on its surface in order to perform the Buchwald reaction in a completely optimal way and in very cost-effective conditions. For this purpose, the reaction temperature was reduced from 100 to 80 and potassium carbonate salt was used to create ionic bonds between the reactants. The composition of the percentage of products obtained by this method is very high and is about 97%, which according to recent research [2-4] in this field, has a much higher efficiency. So that in the first half hour, the desired product is synthesized and with more time, the raw materials are completely consumed and converted into a product. The power of the nanocatalyst is so high that, in several re-uses, it is reduced by less than 10% of its power, which is a very good figure for more reactions and clearly shows the high efficiency of this nanocatalyst.