A green method for confirming the Sonogashira reaction with magnetic nanoparticles

Abstract

Today, many catalysts are designed and synthesized to perform chemical reactions, which is very efficient in the chemical and medical industries [1]. Therefore, the first step in the synthesis of a magnetic nanocatalyst with a magnetic property called magnetite nanocatalyst is to form a nuclear / shell structure and its nanoparticles are confirmed by SEM, TEM analysis. The Fe3O4 magnetic nanocatalyst, obtained by combining two metal salts, iron 2 and iron 3, in a ratio of 1: 2 in distilled water, at room temperature and weighing 0.005 g, is surrounded by a silica coating (SiO2, to prevent Excess oxidation of its surface). In the next step, the trimethoxyl-isylpropyl chloride linker is first bonded to the silica cores, and along it, the morpholine linker is covalently bonded to the previous linker, and the overall structure of the nanocatalyst becomes regular and integrated. Finally, to increase the efficiency of the catalyst in many reactions such as carbon-carbon triple coupling reaction (sonogashira coupling reaction), 2 acetate nanoparticles are coated on the surface of the catalyst with connected linkers and prepare the nanocatalyst surface for this reaction. The reaction conditions were as follows: from a solvent of ethanol used (as green solvent) and triethylamine base to bind two triple bonds together at 75° C, completely green products with efficiencies above 98% were obtained. The efficiency of this magnetic nanocatalyst is very high and its features include synthesis using inexpensive materials, physico-chemical connection between aqueous and organic phases, creation of high efficiency products and easy extraction by external field. By comparing the results of this reaction with the research reactions of other researchers [2-4], the efficiency and high power of 96% of this catalyst in performing Sonogashira reaction several times during ten periods showed.