A Hydrophilic Heterogeneous Copper Nanocatalyst for Suzuki Coupling Reaction in Water

Abstract

Suzuki-Miyaura cross-coupling reaction of aryl halides with arylboronic acids catalyzed by copper compounds provides a versatile synthetic tool for the formation of biaryls as essential motifs found in bioactive compounds and pharmaceuticals [1]. As a cheap, safe, non-toxic, and green medium, water has attracted considerable interest for organic reactions. Some effective ligands with metals can catalyze the reactions efficiently in water, which is attributed to the Breslow hydrophobic effect, hydrogen bonding effect, and polarity effect [2]. magnetic nanoparticles as the support for catalysts have attracted increasing attention because of their facile separation from the reaction mixture using an external magnet [3]. Here, we have immobilized copper (II) onto magnetic nanoparticles stabilized by a hydrophilic ligand and applied it as a nanocatalyst in the Suzuki cross-coupling reaction