Efcient synthesis of spirooxindole derivatives by magnetic and recyclable CaFe2O4@MgAl‑LDH

Abstract

A promising chemotherapeutic agent is spirooxindole. Probable targets involve cancers of the lung, liver, breast, colon, stomach, and prostate. Widespread drug discovery applications and biological activity are signifcant synthetic targets of spirooxindoles. In the present study, the synthesis of CaFe2O4 nanoparticles via the sol–gel method is discussed. Vibrating sample magnetometer, scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray difraction were used to prepare and characterize CaFe2O4@MgAl-LDH as an efective catalyst for the preparation of spirooxindole derivatives via one-pot, the three-component reaction of malononitrile, CH-acids (1,3-dicarbonyl compounds), and isatin in the presence of CaFe2O4@MgAl-LDH in excellent yields with short reaction times in aqueous media is used to describe a facile and efcient multicomponent synthesis of functionalized spirooxindoles.