Authors | Mohammad Hossein Sayadi,Azadi Nammam Ali,Blahova Jana,Fathi Mokhtar,Miglietta Maria Lucia,Pirsaheb Maghdad |
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Journal | Chemosphere |
Page number | 904-915 |
Serial number | 215 |
Volume number | 4 |
IF | 3.137 |
Paper Type | Full Paper |
Published At | 2019 |
Journal Grade | ISI |
Journal Type | Typographic |
Journal Country | Iran, Islamic Republic Of |
Journal Index | JCR،Scopus |
Abstract
The aim of present study was to assess the toxicological effects of transition metal-doped titanium dioxide nanoparticles (TiO2 NPs) on histopathological changes, behavioral patterns, and antioxidant responses of goldfish (Carassius auratus) and common carp (Cyprinus carpio). The synthesized nanoparticles were confirmed by Transmission Electron Microscopy, Field Emission Scanning Electron Microscopy, X-ray diffraction, UV–visible, and Vibration Sample Magnetometer. Fish in four experimental groups exposed to sub-lethal concentrations of pure TiO2 NPs (10 mg L−1), chromium (Cr), iron (Fe), and nickel (Ni) doped TiO2 NPs for seven days. Statistical analysis of oxidative stress responses in gills showed significant differences in superoxide dismutase, total antioxidant capacity, and malondialdehyde parameters between two species and in all parameters than glutathione peroxidase between experimental groups and control group. In intestine, no significant difference was observed among groups, but oxidative responses were markedly different in all parameters among fish species. The histopathological analysis showed hyperplasia, fusion, and aneurism in the gills as well as degeneration, integration of villi, necrosis and erosion of the intestine. Our findings indicated that compare to pure TiO2 NPs, exposure to transition metals-doped TiO2 NPs induced oxidative stress and histopathological changes in both fish species.
tags: Transition metalTiO2 NPsFishAntioxidant responseHistopathological damages