| Authors | Mohammad Reza Ganjali,Michal Alexovič,Mehdi Erfani Jazi,Hadi Tabani |
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| Journal | Bioanalysis |
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| Page number | 1401-1413 |
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| Serial number | 13 |
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| Volume number | 18 |
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| Paper Type | Full Paper |
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| Published At | 2021 |
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| Journal Grade | ISI |
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| Journal Type | Electronic |
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| Journal Country | Iran, Islamic Republic Of |
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| Journal Index | ISI،JCR،Scopus |
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Abstract
Aim: Hollow-fiber-based supported liquid membrane was modified utilizing nanostructures such as graphite, graphene oxide or nitrogen-doped graphene oxide, for electro-membrane extraction (EME) of imatinib and sunitinib from biological fluids. By applying these conductive nanostructures, a low-voltage EME device (6.0 V) was fabricated. Materials & methods: A response surface methodology through central composite design was used to evaluate and optimize effects of various essential factors that influence on normalized recovery. Results: Optimal extraction conditions were set as, 1-octanol with 0.01 % (w/v) graphene oxide functioning as the supported liquid membrane, an extraction time of 17.0 min, pH of the acceptor and the donor phase of 2.8 and 7.9, respectively. Conclusion: The method was successfully applied to quantify imatinib and sunitinib in biological fluids.
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