The Effects of Resistance and Endurance Training on Nesfatin-1 HSP70 Insulin Resistance and Body Composition Levels in Women with Type 2 Diabetes Mellitus

Abstract

Objectives. — Nesfatin-1 and HSP70 are involved in the regulating mechanisms of insulin and glucose metabolism. The aim of this study was to evaluate the effects of 10 weeks of resistance and endurance exercise training on the serum levels of nesfatin-1, HSP70 and insulin resistance (IR) in women with type 2 diabetes. Materials and Methods. — 26 women with type 2 diabetes were selected using purposive sampling and were randomly divided into three groups. 10 subjects participated in the resistance training group (3 sessions per week, exercising with 30—80% of one repetition maximum (1RM)), 8 subjects participated in the endurance training group (3 sessions per week, exercising with 40—80% of maximum heart rate (HR max), for 20—45 minutes), and 8 subjects were placed in the control group who did not engage in any physical exercise during the study period. Blood samples were collected after a 12 hour [overnight]fast in order to evaluate nesfatin-1, HSP70, insulin and glucose levels in the pre- and post-tests.The obtained data were analyzed using the Kolmogorov-Smirnov (K-S) test, paired-samples t-test, one-way ANOVA and LSD post-hoc test in SPSS software, version 21 at the significance levelof <0.05.Results. — There was a significant increase in nesfatin-1 levels and a significant decrease inHSP70 levels of the resistance training group, (P < 0.05), whereas no significant changes wereobserved in nesfatin-1 and HSP70 levels of the endurance training group (P > 0.05). Glucoselevels, insulin resistance (HOMA1-IR) and body composition indices (except for WHR) signifi-cantly decreased in both training groups (P < 0.05). However, there were no significant changesin insulin levels of the training groups (P > 0.05). Moreover, comparing the pre- and post-testlevels of glucose changes, a significant difference was observed in the resistance and endurancetraining groups but not in the control group (P < 0.05).Conclusion. — Resistance and endurance training are recommended as complementary therapyfor women with type 2 diabetes mellitus.