Effect of exercise training type on plasma levels of vaspin, nesfatin-1, and high-sensitivity C-reactive protein in overweight and obese women

Abstract

Background: Vaspin, nesfatin-1 and high-sensitivity C-reactive protein (hs-CRP) act as main risk factors of inflammation and cardiovascular health. There are contradictory results about the effects of exercise training on these obesity-related factors. Therefore, the purpose of present study was to elucidate the effect of exercise training type on plasma levels of vaspin, hs-CRP, and nesfatin-1 in overweight and obese women. Methods: Thirty-four overweight and obese women (age 22.29 ± 2.49 years) were randomly assigned to the endurance, resistance and sedentary control groups. The 8-week endurance and resistance exercise trainings were conducted at 65–80% of maximal heart rate and one repetition maximum, respectively. Fasting blood samples were taken before and 48-hr after the last exercise training session. The serum concentrations of vaspin, nesfatin-1 and hs-CRP were measured using commercially available ELISA kit. The intra- and inter-group comparisons were performed by t-test and one-way ANOVA at a significant level of P < 0.05, respectively. Results: Both of exercise trainings caused a significant reduction in plasma levels of vaspin (P = 0.001 and P = 0.005 for endurance and resistance exercise trainings, respectively) and hs-CRP (P = 0.008 and P = 0.007 for endurance and resistance exercise trainings, respectively). In contrast, a significant increase in plasma levels of nesfatin-1 (P = 0.001 for both of endurance and resistance exercise trainings) and maximal oxygen consumption (P = 0.001 and P = 0.003 for endurance and resistance exercise trainings, respectively) were obtained. Conclusions: Both of endurance and resistance exercise training protocols promote the cardiovascular health of overweight and obese women by improving obesity-related factors