تأثیر هشت هفته تمرین هوازی و عصاره چای سبز بر برخی عوامل التهابی در بافت پروستات موشهای سالم

Abstract

Introduction: Lifestyle modification is an important aspect of preventing various diseases, including various types of cancer. The aim of the present study was to investigate the effect of eight weeks of aerobic training and green tea extract on levels of nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2) and suppressor protein of p53 in prostate tissue of healthy rats. Materials and Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups: green tea extract, exercise training, green tea extract + exercise training, and control. The exercise training program included aerobic training on a low to moderate intensity on the treadmill (at a speed of 3-10 m/s, 3 sets of 15 min with 2 min of rest between sets, 5 days a week). Green tea extract was gavaged at a dose of 1.3 ml of solution at a concentration of 10 mg/100 ml (3 sessions per week). Scarify was performed 48 hours after the end of the intervention. The results were analyzed using parametric statistical methods of analysis of covariance and one way ANOVA. Results: Aerobic training significantly increased NF-κB protein level compared to the control group (P = 0.02), but the combination of aerobic training and consumption of green tea extract did not significantly change the NF-κB protein level. The COX-2 and p53 protein levels did not change significantly after aerobic training and consumption of green tea extract (P > 0.05). Conclusion: It seems that green tea consumption can modulate the NF-κB level following aerobic training, which indicates the anti-inflammatory effects of green tea and its possible role in preventing prostate cancer.